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deskgameNFL Week 12 begins with an old-school AFC North rivalry and concludes with a made-for-TV matchup between head coaches who are brothers. deskgameAs previously indicated, Buffalo checked a first box to being regarded as an authentic top-shelf contender by knocking the Chiefs down for the first time this season. The Ravens have their obvious defensive concerns, and while Pittsburgh (+900) may field the best defense in the AFC, it doesn’t quite have enough on offense to match the Bills and Chiefs overall on both sides of the ball. deskgameThe Penn State rushing game is another strength that can spur an Orange Bowl victory. Kaytron Allen and Nicholas Singleton are the first PSU duo to rush for over 1,000 yards in a season. They are the only 1,000-yard running back pairing in the FBS this season. The ground game and opportunistic defense can be primary routes to a Nittany Lions win. deskgameDefense will be a point of emphasis for both teams, as the Eagles' secondary has allowed the third-fewest passing yards this season. Jayden Daniels has been less productive through the air since his injury against Carolina, so going under this mark seems likely on a short week.